Gene Expression Is Circular: Factors for mRNA Degradation Also Foster mRNA Synthesis
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چکیده
منابع مشابه
Gene Expression Is Circular: Factors for mRNA Degradation Also Foster mRNA Synthesis
Maintaining proper mRNA levels is a key aspect in the regulation of gene expression. The balance between mRNA synthesis and decay determines these levels. We demonstrate that most yeast mRNAs are degraded by the cytoplasmic 5'-to-3' pathway (the "decaysome"), as proposed previously. Unexpectedly, the level of these mRNAs is highly robust to perturbations in this major pathway because defects in...
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ژورنال
عنوان ژورنال: Cell
سال: 2013
ISSN: 0092-8674
DOI: 10.1016/j.cell.2013.05.012